Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin
نویسندگان
چکیده
منابع مشابه
Thyroid dysfunction in Turkish patients with chronic hepatitis C receiving peginterferon plus ribavirin in the period of 2005-2010.
Interferon-α based therapy for chronic hepatitis C (CHC) is associated with thyroiditis and thyroid dysfunction (TD). This study investigated whether TD during pegylated interferon-α (PEG-IFN) plus ribavirin treatment favors sustained viral response (SVR), and also the association between TD and PEG-IFN formulations. This retrospective study was performed in CHC patients who had received PEG-IF...
متن کاملPeginterferon and ribavirin for chronic hepatitis C.
n engl j med 355;23 www.nejm.org december 7, 2006 2444 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are p...
متن کامل[Results of treatment with peginterferon plus ribavirin in patients with chronic hepatitis C].
BACKGROUND The current treatment recommendation for chronic hepatitis C virus infection is the combination of peginterferon and ribavirin for 24 or 48 weeks, depending on the viral genotype. The aim of the therapy is to obtain a sustained virological response. AIM To report our experience in the treatment of chronic hepatitis C. MATERIAL AND METHODS Analysis of 52 patients treated between S...
متن کاملRoles of ITPA and IL28B Genotypes in Chronic Hepatitis C Patients Treated with Peginterferon Plus Ribavirin
It has been reported that inosine triphosphatase (ITPA) gene variants protect against ribavirin-induced anemia in patients treated for chronic hepatitis C. IL28B variants also influence the treatment response of peginterferon plus ribavirin treatment in these patients. In the present study, we examined how ITPA and IL28B genotypes have clinical impacts on treatment-induced hematotoxicities and ...
متن کاملFactors influencing therapeutic response to peginterferron plus ribavirin in the different genotypes of chronic hepatitis C
Abstract Background: Different factors like age, sex, route of infection, initial viral load, levels of liver function tests and genotypes may affect response to treatment in patients with chronic hepatitis C. The purpose of this study was to determine the role of these factors in the treatment of these patients. Methods: From 2004 to 2012, different genotypes of chronic HCV (Hepatitis C ...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2012
ISSN: 0269-2813
DOI: 10.1111/j.1365-2036.2012.05109.x